Methylation and transcriptomic profiling reveals short term and long term regulatory responses in polarized macrophages.

ABSTRACT: Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation of epigenetic changes can be used to understand how temporary stimuli can result in lasting effects. Epigenetic alterations play an important role in the pathophysiology of macrophages, including their trained innate immunity, enabling faster and more efficient inflammatory responses upon subsequent encounters to the same pathogen or insult. In this study, we used a multi-omics approach to elucidate the interplay between gene expression and DNA-methylation, to explore the potential long-term effects of diverse polarizing environments on mac

SUBMITTER: Migliaccio G 

PROVIDER: S-EPMC11385784 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature