Assessment of immune responses to a Comirnaty® booster following CoronaVac® vaccination in healthcare workers.

ABSTRACT:

Background

The immunological response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and immunisation is variable.

Objectives

To describe the humoral immune response by correlating IgA and IgG antibodies with NAbs titration following CoronaVac® immunisation and an mRNA (Comirnaty®) booster among healthcare workers (HCWs) and to compare the cytokine and interleukin profiles between HCWs vaccinated with CoronaVac and coronavirus disease 2019 (COVID-19) infected patients.

Methods

Samples from 133 HCWs collected at 20 (T1) and 90 (T2) days after CoronaVac immunisation and 15 (T3) days after a booster dose with the Comirnaty vaccine were analysed for IgA and IgG EIA and neutralisation assay. Cytokine levels from vaccinated individuals at T1 day a

SUBMITTER: Bochnia-Bueno L 

PROVIDER: S-EPMC11385826 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature