IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages.

ABSTRACT:

Background

Targeting the tumor microenvironment represents an emerging therapeutic strategy for cancer. Macrophages are an essential part of the tumor microenvironment. Macrophage polarization is modulated by mitochondrial metabolism, including oxidative phosphorylation (OXPHOS), the tricarboxylic acid (TCA) cycle, and reactive oxygen species content. Isocitrate dehydrogenase 2 (IDH2), an enzyme involved in the TCA cycle, reportedly promotes cancer progression. However, the mechanisms through which IDH2 influences macrophage polarization and modulates tumor growth remain unknown.

Methods

In this study, IDH2-deficient knockout (KO) mice and primary cultured bone marrow-derived macrophages (BMDMs) were used. Both in vivo subcutaneous tumor experiments and in vitro co-culture e

SUBMITTER: Lee SW 

PROVIDER: S-EPMC11385829 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature