Quantitative Perfusion-Weighted Magnetic Resonance Imaging in Uveal Melanoma.

ABSTRACT:

Purpose

Perfusion-weighted imaging (PWI; magnetic resonance imaging [MRI]) has been shown to provide valuable biological tumor information in uveal melanoma (UM). Clinically used semiquantitative methods do not account for tumor pigmentation and eye movement. We hypothesize that a quantitative PWI method that incorporates these, provides a more accurate description of tumor perfusion than the current clinical method. The aim of this study was to test this in patients with UM before and after radiotherapy.

Methods

Perfusion-weighted 3T MRIs were retrospectively analyzed in 47 patients with UM before and after radiotherapy. Tofts pharmacokinetic modeling was performed to determine vascular permeability (Ktrans), extracellular extravascular space (ve), and reflux rate (kep). Th

SUBMITTER: Klaassen L 

PROVIDER: S-EPMC11385876 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature