Targeting TAG-72 in cutaneous T cell lymphoma.

ABSTRACT:

Purpose

Current monoclonal antibody-based treatment approaches for cutaneous T cell lymphoma (CTCL) rely heavily on the ability to identify a tumor specific target that is essentially absent on normal cells. Herein, we propose tumor associated glycoprotein-72 (TAG-72) as one such target. TAG-72 is a mucin-associated, truncated O-glycan that has been identified as a chimeric antigen receptor (CAR)-T cell target in solid tumor indications. To date, TAG-72 targeting has not been considered in the setting of hematological malignancies.

Experimental design

CD3⁺ cells from patients with CTCL were analyzed for TAG-72 expression by flow cytometry. Immunohistochemistry was used to assess TAG-72 expression in CTCL patient skin lesions and a TAG-72 ELISA was employed to asse

SUBMITTER: Evtimov VJ 

PROVIDER: S-EPMC11386021 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature