Further insights into anti-IgLON5 disease: a case with complex clinical presentation.

ABSTRACT:

Background

Anti-IgLON5 disease is an autoimmune encephalitis overlapping with neurodegenerative disorders due to pathological accumulation of hyperphosphorylated tau. It is characterized by several clinical manifestations determined by involvement of different brain areas, and mild response to first-line immunotherapies. We report a case of anti-IgLON5 disease with a multifaceted semiology and an unusually good response to glucocorticoid monotherapy.

Case presentation

A 68-year-old man with type 2 diabetes was evaluated for an 8-month history of progressive gait disorder causing frequent falls. He also suffered from obstructive sleep apneas and complained of dysphonia, dysarthria, occasional dysphagia, urinary incontinence, and upper limb action tremor. Neurological examinat

SUBMITTER: Pierro S 

PROVIDER: S-EPMC11386077 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature