The association between cumulative exposure to PM_2.5 and DNA methylation measured using methyl-capture sequencing among COPD patients.

ABSTRACT:

Background

Particulate matter with a diameter of < 2.5 μm (PM_2.5) influences gene regulation via DNA methylation; however, its precise mechanism of action remains unclear. Thus, this study aimed to examine the connection between personal PM_2.5 exposure and DNA methylation in CpG islands as well as explore the associated gene pathways.

Methods

A total of 95 male patients with chronic obstructive pulmonary disease (COPD) were enrolled in this study. PM_2.5 concentrations were measured for 12 months, with individual exposure recorded for 24 h every 3 months. Mean indoor and estimated individual PM_2.5 exposure levels were calculated for short-term (7 days), mid-term (35 days), and long-term (90 days). DNA methylation analysis was perfor

SUBMITTER: Ji HW 

PROVIDER: S-EPMC11386081 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature