MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression.

ABSTRACT:

Background

Visceral adipose tissue in individuals with obesity is an independent cardiovascular risk indicator. However, it remains unclear whether adipose tissue influences common cardiovascular diseases, such as atherosclerosis, through its secreted exosomes.

Methods

The exosomes secreted by adipose tissue from diet-induced obesity mice were isolated to examine their impact on the progression of atherosclerosis and the associated mechanism. Endothelial apoptosis and the proliferation and migration of vascular smooth muscle cells (VSMCs) within the atherosclerotic plaque were evaluated. Statistical significance was analyzed using GraphPad Prism 9.0 with appropriate statistical tests.

Results

We demonstrate that adipose tissue-derived exosomes (AT-EX) exacerbate ather

SUBMITTER: Guo B 

PROVIDER: S-EPMC11386123 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature