Small airway inflammation in atypical asthma.

ABSTRACT:

Background

Less attention has been paid to the pathophysiological changes in atypical asthma such as cough variant asthma (CVA) and chest tightness variant asthma (CTVA). The obstruction of large and small airways is the important component in the development of asthma. We investigated whether small airway inflammation (SAI) induced small airway dysfunction (SAD) in these atypical asthmatics.

Methods

Six hundred and eighty-six patients were enrolled and analyzed in the study. The partitioned airway inflammation was assessed by fractional exhaled nitric oxide (FeNO), such as FnNO, FeNO₅₀, FeNO₂₀₀, and calculated alveolar fraction of exhaled NO (CaNO_dual). Correlations between exhaled NOs and SAD-related variables were assessed, whereas cell cl

SUBMITTER: Han J 

PROVIDER: S-EPMC11386289 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature