Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study.

ABSTRACT:

Introduction

High-dose methotrexate (HDMTX) use can be limited by the development of acute kidney injury (AKI). Early AKI detection is paramount to prevent further renal injury and irreversible toxicities. This study sought to determine whether early elimination patterns of MTX would be useful as a biomarker of AKI in HDMTX treatment.

Methods

This retrospective cohort study included two sites that collected ≥2 MTX levels within 16 h from completion of MTX infusion. Early levels were tagged and MTX elimination half-life (t_½) were calculated from combinations of two of three different early time periods. Receiver operating characteristic (ROC) curves were synthesized for each elimination t_½ (biomarker) with respect to AKI and delayed methotrexate eliminat

SUBMITTER: Tentoni N 

PROVIDER: S-EPMC11386298 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature