Clinical and molecular response to alpha1-oleate treatment in patients with bladder cancer.

ABSTRACT:

Background

The tumoricidal complex alpha1-oleate targets bladder cancer cells, triggering rapid, apoptosis-like tumor cell death. Clinical effects of alpha1-oleate were recently observed in patients with non-muscle invasive bladder cancer (NMIBC), using a randomized, placebo-controlled study protocol.

Aims

To investigate if there are dose-dependent effects of alpha1-oleate.

Materials and methods

Here, patients with NMIBC were treated by intravesical instillation of increasing concentrations of alpha1-oleate (1.7, 8.5, or 17 mM) and the treatment response was defined relative to a placebo group.

Results

Strong, dose-dependent anti-tumor effects were detected in alpha1-oleate treated patients for a combination of molecular and clinical indicators; a complete or p

SUBMITTER: Haq F 

PROVIDER: S-EPMC11386334 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature