Genome-centric metagenomes unveiling the hidden resistome in an anchialine cave.

ABSTRACT:

Background

Antibiotic resistance is a critical global concern, posing significant challenges to human health and medical treatments. Studying antibiotic resistance genes (ARGs) is essential not only in clinical settings but also in diverse environmental contexts. However, ARGs in unique environments such as anchialine caves, which connect both fresh and marine water, remain largely unexplored despite their intriguing ecological characteristics.

Results

We present the first study that comprehensively explores the occurrence and distribution of ARGs and mobile genetic elements (MGEs) within an anchialine cave. Utilizing metagenomic sequencing we uncovered a wide array of ARGs with the bacitracin resistance gene, bacA and multidrug resistance genes, being the most dominant. The

SUBMITTER: Vojvoda Zeljko T 

PROVIDER: S-EPMC11386340 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature