Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.

ABSTRACT:

Background

The association between education, intelligence, and cognition with digestive tract diseases has been established. However, the specific contribution of each factor in the pathogenesis of these diseases are still uncertain.

Method

This study employed multivariable Mendelian randomization (MR) to assess the independent effects of education, intelligence, and cognition on gastrointestinal conditions in the FinnGen and UK Biobank European-ancestry populations. A two-step MR approach was employed to assess the mediating effects of the association.

Results

Meta-analysis of MR estimates from FinnGen and UK Biobank showed that 1- SD (4.2 years) higher education was causally associated with lower risks of gastroesophageal reflux (OR: 0.58; 95% CI: 0.50, 0.66), pept

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11386375 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature