The interplay of brain neurotransmission and mental fatigue: A research protocol.

ABSTRACT:

Introduction

Mental fatigue (MF) significantly affects both cognitive and physical performance. However, the precise mechanisms, particularly concerning neurotransmission, require further investigation. An implication of the role of dopamine (DA) and noradrenaline (NA) is stated, but empirical evidence for this theory still needs to be provided. To address this gap, we aim to investigate the role of brain neurotransmission in elucidating if, and how prolonged cognitive activity induces MF and its subsequent impact on cognitive performance.

Methods

This study (registration number: G095422N) will adopt a randomized cross-over design with sixteen healthy participants aged 18-35 years. The sessions include a familiarization, two experimental (DA: 20mg Methylphenidate; NA: 8mg Re

SUBMITTER: Arenales Arauz YL 

PROVIDER: S-EPMC11386444 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature