COVID-19 Breakthrough Infections Among People With HIV: A Statewide Cohort Analysis.

ABSTRACT:

Objectives

This study aims to identify COVID-19 breakthrough infections among people with HIV (PWH) across different phases of the pandemic and explore whether differential immune dysfunctions are associated with breakthrough infections.

Design and methods

This retrospective population-based cohort study used data from an integrated electronic health record (EHR) database in South Carolina (SC). Breakthrough infection was defined as the first COVID-19 diagnosis documented in the state agency after the date an individual was fully vaccinated (ie, 2 doses of Pfizer/BNT162b2 or Moderna/mRNA-1273, or 1 dose of Janssen/Ad26.COV2.S) through June 14, 2022. We analyzed the risk and associated factors of the outcome using Cox proportional hazards models.

Results

Among 7596 ful

SUBMITTER: Yang X 

PROVIDER: S-EPMC11386905 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature