Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.

ABSTRACT: There is growing interest in designing multidrug therapies that leverage tradeoffs to combat resistance. Tradeoffs are common in evolution and occur when, for example, resistance to one drug results in sensitivity to another. Major questions remain about the extent to which tradeoffs are reliable, specifically, whether the mutants that provide resistance to a given drug all suffer similar tradeoffs. This question is difficult because the drug-resistant mutants observed in the clinic, and even those evolved in controlled laboratory settings, are often biased towards those that provide large fitness benefits. Thus, the mutations (and mechanisms) that provide drug resistance may be more diverse than current data suggests. Here, we perform evolution experiments utilizing lineage-tracking to ca

SUBMITTER: Schmidlin K 

PROVIDER: S-EPMC11386965 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature