The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis.

ABSTRACT: Epithelial homeostasis can be critically influenced by how cells respond to mechanical forces, both local changes in force balance between cells and altered tissue-level forces.¹ Coupling of specialized cell-cell adhesions to their cytoskeletons provides epithelia with diverse strategies to respond to mechanical stresses.^2,3,4 Desmosomes confer tissue resilience when their associated intermediate filaments (IFs)^2,3 stiffen in response to strain,^{5,6,7,8,9,10,11} while mechanotransduction associated with the E-cadherin apparatus^12,

SUBMITTER: Nanavati BN 

PROVIDER: S-EPMC11387132 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature