Adhesion of retinal cells to gold surfaces by biomimetic molecules.

ABSTRACT:

Background

Neural cell-electrode coupling is crucial for effective neural and retinal prostheses. Enhancing this coupling can be achieved through surface modification and geometrical design to increase neuron-electrode proximity. In the current research, we focused on designing and studying various biomolecules as a method to elicit neural cell-electrode adhesion via cell-specific integrin mechanisms.

Methods

We designed extracellular matrix biomimetic molecules with different head sequences (RGD or YIGSR), structures (linear or cyclic), and spacer lengths (short or long). These molecules, anchored by a thiol (SH) group, were deposited onto gold surfaces at various concentrations. We assessed the modifications using contact angle measurements, fluorescence imaging, and X-ray

SUBMITTER: Shpun G 

PROVIDER: S-EPMC11387177 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature