Mutation patterns in colorectal cancer and their relationship with prognosis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a prevalent malignancy and a leading cause of cancer-related mortality. Extensive research into the aetiology of CRC has revealed that somatic mutations in certain genes play a crucial role in CRC development.AIM: In this study, we utilized data from public databases to investigate prevalent mutation patterns in CRC and developed a prognostic predictive model for CRC patients based on mutant genetic characteristics and other relevant clinical features.

Methods

We initially gathered mutation information from CRC patients by analysing data from 15 datasets to identify genes with a mutation frequency of ≥10 %. Next, log-rank analyses were used to determine the relationship between prognosis and the mutational status of the most commonly mut

SUBMITTER: Su Z 

PROVIDER: S-EPMC11387246 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature