Link between persistent, unexplained gamma-glutamyltransferase elevation and porto-sinusoidal vascular disorder.

ABSTRACT:

Background & aims

Porto-sinusoidal vascular disorder (PSVD) is a group of vascular disorders characterized by lesions involving portal venules and sinusoids, irrespective of the presence of portal hypertension. Liver biopsy is essential for diagnosis. In a single-center study, we demonstrated high rates of PSVD in patients with persistently elevated gamma-glutamyltransferase (GGT). This multicenter study aims to establish PSVD prevalence in a larger dataset of individuals with persistent and unexplained GGT elevation, and to identify associated risk factors.

Methods

The study included all patients who underwent liver biopsy for persistent and unexplained GGT elevation in five Italian hepatology units between March 2015 and December 2021.

Results

A total of 144 patient

SUBMITTER: Pugliese N 

PROVIDER: S-EPMC11387327 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature