Fast-acting antidepressant-like effects of ketamine in aged male rats.

ABSTRACT:

Background

The aging process causes anatomical and physiological changes that predispose to the development of late-life depression while reduces the efficacy of classical antidepressants. Novel fast-acting antidepressants such as ketamine might be good candidates to be explored in the context of aging, especially given the lack of previous research on its efficacy for this age period. Thus, the aim of the present study was to characterize ketamine's effects in older rats.

Methods

The fast-acting (30 min) and repeated (7 days) antidepressant-like effects of ketamine (5 mg/kg, ip) were evaluated in 14-month-old single-housed rats through the forced-swim and novelty-suppressed feeding tests. In parallel, the modulation of neurotrophic-related proteins (i.e., mBDNF, mTOR, GSK3)

SUBMITTER: Hernandez-Hernandez E 

PROVIDER: S-EPMC11387441 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature