Uncovering the unique characteristics of different groups of 5-HT_5AR ligands with reference to their interaction with the target protein.

ABSTRACT:

Background

The serotonin 5-HT_5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being increasingly recognized, and the possibilities that lie ahead of these findings. There is a growing body of evidence indicating that these ligands have procognitive, pro-social, and anti-depressant properties, which offers new avenues for the development of treatments that could address socially important conditions related to the malfunctioning of the central nervous system. The aim of our study was to unravel the molecular determinants for 5-HT_5AR ligands that govern their activity towards the receptor.

Methods

In response to the need for identification of molecular determinants for 5-HT_5AR activity, we

SUBMITTER: Kordylewski SK 

PROVIDER: S-EPMC11387456 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature