Role of [¹⁸F]FAPI-04 in staging and therapeutic management of intrahepatic cholangiocarcinoma: prospective comparison with [¹⁸F]FDG PET/CT.

ABSTRACT:

Background

Fluorine-18 fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) has some limitations in diagnosis of Intrahepatic cholangiocarcinoma (ICC).

Materials and methods

Patients with histologically confirmed ICC who underwent both [¹⁸F]FDG and ¹⁸F-labeled fibroblast-activation protein inhibitors ([¹⁸F]FAPI)-04 PET/CT were prospectively analyzed. The maximum standard uptake value (SUV_max), tumor-to-background ratio (TBR), metabolic tumor volume (MTV), total lesion glycolysis (TLG), [¹⁸F]FAPI-avid tumor volume (FTV), total lesion fibroblast activation protein expression (TLF) were compared between the two modalities by paired Wilcoxon signed-rank test and Mann-Whitney U te

SUBMITTER: Liang J 

PROVIDER: S-EPMC11387567 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature