Concept and location neurons in the human brain provide the 'what' and 'where' in memory formation.

ABSTRACT: Our brains create new memories by capturing the 'who/what', 'where' and 'when' of everyday experiences. On a neuronal level, mechanisms facilitating a successful transfer into episodic memory are still unclear. We investigated this by measuring single neuron activity in the human medial temporal lobe during encoding of item-location associations. While previous research has found predictive effects in population activity in human MTL structures, we could attribute such effects to two specialized sub-groups of neurons: concept cells in the hippocampus, amygdala and entorhinal cortex (EC), and a second group of parahippocampal location-selective neurons. In both item- and location-selective populations, firing rates were significantly higher during successfully encoded trials. These findings

SUBMITTER: Mackay S 

PROVIDER: S-EPMC11387663 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature