Improved survival of patients with stage III small-cell lung cancer with primary resection: A SEER-based analysis.

ABSTRACT:

Introduction

Small cell lung cancer (SCLC) is mostly diagnosed in stage III-IV patients and associated with poor prognosis. To date, surgery is no gold-standard treatment for any SCLC stage and evidence is lacking whether it is beneficial. Here we investigate the impact of surgery, with special attention to stage III SCLC patients, sub-stages and treatment combinations.

Methods

The overall survival (OS) and cancer-specific survival (CSS) of 33,198 SCLC patients (SEER database) were analyzed retrospectively, using various statistical analyses, including propensity score matching (PSM), recursive partitioning, and sequential landmark analyses.

Results

Independent of stage, the OS of patients with surgery-including treatments was almost always better than without surgery

SUBMITTER: Jia J 

PROVIDER: S-EPMC11387713 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature