Dialkylation of CF₂ unit enabled by cobalt electron-shuttle catalysis.

ABSTRACT: The incorporation of difluoromethylene (CF₂) group into chemical molecules often imparts desirable properties such as lipophilicity, binding affinity, and thermal stability. Consequently, the increasing demand for gem-difluoroalkylated compounds in drug discovery and materials science has continued to drive the development of practical methods for their synthesis. However, traditional synthetic methods such as deoxofluorination often confront challenges including complicated substrate synthesis sequences and poor functional group compatibility. In this context, we herein report a metal electron-shuttle catalyzed, modular synthetic methodology for difluoroalkylated compounds by assembling two C(sp³) fragments across CF₂ unit in a single step. The approach ha

SUBMITTER: Rao C 

PROVIDER: S-EPMC11387730 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature