HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis.

ABSTRACT: Nitrogen (N) deficiency responses are essential for plant survival and reproduction. Here, via an expression genome-wide association study (eGWAS), we reveal a mechanism that regulates microRNA (miRNA) dynamics necessary for N deficiency responses in Arabidopsis. Differential expression levels of three NAC transcription factor (TF) genes involved in leaf N deficiency responses among Arabidopsis accessions are most significantly associated with polymorphisms in HASTY (HST), which encodes an importin/exportin family protein responsible for the generation of mature miRNAs. HST acts as a negative regulator of N deficiency-induced leaf senescence, and the disruption and overexpression of HST differently modifies miRNA dynamics in response to N deficiency, altering levels of miRNAs targeting tra

SUBMITTER: Sakuraba Y 

PROVIDER: S-EPMC11387735 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature