Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits.

ABSTRACT: Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug disposition in the body. Rabbits play a pivotal role as a highly valued small animal model, particularly in the field of ocular therapeutics, where they serve as a crucial link between preclinical research and clinical applications. In this context, we have developed PBPK models designed specifically for rabbits, with a focus on accurately predicting the pharmacokinetic profiles of protein therapeutics following intravenous administration. Our goal was to comprehend the influence of key physiological factors on systemic disposition of antibodies and their functional derivatives. For the development of the systemic PBPK models, rabbit physiological factors such as gene expression, body weight, neonat

SUBMITTER: Jairam RK 

PROVIDER: S-EPMC11387799 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature