Preserved functional organization of auditory cortex in two individuals missing one temporal lobe from infancy.

ABSTRACT: Human cortical responses to natural sounds, measured with fMRI, can be approximated as the weighted sum of a small number of canonical response patterns (components), each having interpretable functional and anatomical properties. Here, we asked whether this organization is preserved in cases where only one temporal lobe is available due to early brain damage by investigating a unique family: one sibling missing their left temporal lobe from infancy, another missing the right temporal lobe from infancy, and a third anatomically neurotypical. None of the siblings manifested behavioral deficits. We analyzed fMRI responses to diverse natural sounds within the intact hemispheres of these individuals and compared them to 12 neurotypical participants. All siblings manifested typical-like auditor

SUBMITTER: Regev TI 

PROVIDER: S-EPMC11387894 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature