Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a common and debilitating disorder manifesting with abdominal pain and bowel dysfunction. A mainstay of treatment is dietary modification, including restriction of FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols). A greater response to a low FODMAP diet has been reported in those with a distinct IBS microbiome termed IBS-P. We investigated whether this is linked to specific changes in the metabolome in IBS-P.

Methods

Solid phase microextraction gas chromatography-mass spectrometry was used to examine the faecal headspace of 56 IBS cases (each paired with a non-IBS household control) at baseline, and after four-weeks of a low FODMAP diet (39 pairs). 50% cases had the IBS-P microbial subtype, while

SUBMITTER: Conley TE 

PROVIDER: S-EPMC11388012 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature