Intraoperative nitrous oxide inhalation to prevent chronic postsurgical pain in video-assisted thoracoscopic surgery: a prospective observational cohort study.

ABSTRACT:

Background

Chronic postsurgical pain (CPSP) is a significant detriment to postsurgical recovery. Previous studies have shown that nitrous oxide (N₂O) may produce long-term analgesia and may benefit the prevention of CPSP in Chinese patients. We tested the hypothesis that N₂O is a protective factor against chronic pain after video-assisted thoracoscopic surgery (VATS).

Methods

Two groups of patients with and without N₂O inhalation during VATS in Peking Union Medical College Hospital were recruited. Perioperative information was documented, and postsurgical pain was followed up by telephone. The primary outcome was the presence of CPSP at 6 months postoperatively. Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using a

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11388209 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature