Branched-chain amino acids and risk of lung cancer: insights from mendelian randomization and NHANES III.

ABSTRACT:

Background

Recent studies have observed the relationships of circulatory and dietary intake of branched-chain amino acids (BCAAs) with long-term risk of certain cancers. However, the exact causality of BCAA with lung cancer (LUCA) and its pathological subtypes remains obscure. The aim of this study is to investigate the association between BCAA metabolism and risk of LUCA.

Methods

Here we conducted Mendelian randomization (MR) and observational epidemiological analyses to investigate the association between BCAA and risk of LUCA. With single nucleotide polymorphism (SNP)-phenotype association data extracted from genome-wide association studies (GWAS), we performed univariate and multivariate MR analyses to infer the causal effect of circulatory BCAA concentrations on LUCA. W

SUBMITTER: Li Z 

PROVIDER: S-EPMC11388241 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature