Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona).

ABSTRACT:

Background

Severe and prolonged mpox courses have been described during the 2022-2023 outbreak. Identifying predictors of severe evolution is crucial for improving management and therapeutic strategies. We explored the predictors of mpox severity and tested the association between mpox severity and viral load in biological fluids. We also analysed the predictors of disease duration and kinetics of inflammatory markers and described the viral presence and duration of shedding in biological fluids.

Methods

This multicentre historical cohort study included adults diagnosed with laboratory-confirmed mpox diagnosis between May 2022 and September 2023 at 15 Italian centres. Patients were followed up from the day of diagnosis until clinical recovery. Biological fluids (blood, urine

SUBMITTER: Mazzotta V 

PROVIDER: S-EPMC11388274 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature