A regression predictive model for QuantiFERON-TB Gold Plus^® indeterminate results in immunosuppressed patients.

ABSTRACT:

Background

Screening for latent tuberculosis infection using Interferon-Gamma Release Assays is a routine procedure prior to the initiation of anti-tumor necrosis factor (TNF) biotherapy or immunosuppressive therapy. However, indeterminate results are relatively frequent and are an obstacle to treatment initiation.

Aim

The aim of this cross-sectional study was to estimate the frequency of indeterminate QuantiFERON-TB Gold Plus^® test results in Tunisian patients, and to analyze the potential clinico-biological risk factors associated with these indeterminate results.

Methods

Whole blood samples from 712 patients being monitored for autoimmune diseases and candidates for anti-TNF biotherapy or switch of immunosuppressive therapy were used to screen for latent

SUBMITTER: Bellagha R 

PROVIDER: S-EPMC11388302 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature