Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation.

ABSTRACT: The course of normal development and response to pathology are strongly influenced by biological sex. For instance, female childhood cancer survivors who have undergone cranial radiation therapy (CRT) tend to display more pronounced cognitive deficits than their male counterparts. Sex effects can be the result of sex chromosome complement (XX vs. XY) and/or gonadal hormone influence. The contributions of each can be separated using the four-core genotype mouse model (FCG), where sex chromosome complement and gonadal sex are decoupled. While studies of FCG mice have evaluated brain differences in adulthood, it is still unclear how sex chromosome and sex hormone effects emerge through development in both healthy and pathological contexts. Our study utilizes longitudinal MRI with the FCG mode

SUBMITTER: Yeung J 

PROVIDER: S-EPMC11388377 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature