The deubiquitinase Usp7 in <i>Drosophila melanogaster</i> is required for synaptonemal complex maintenance.

ABSTRACT: Meiosis is a form of cell division that is essential to sexually reproducing organisms and is therefore highly regulated. Each event of meiosis must occur at the correct developmental stage to ensure that chromosomes are segregated properly during both meiotic divisions. One unique meiosis-specific structure that is tightly regulated in terms of timing of assembly and disassembly is the synaptonemal complex (SC). While the mechanism(s) for assembly and disassembly of the SC are poorly understood in Drosophila melanogaster, posttranslational modifications, including ubiquitination and phosphorylation, are known to play a role. Here, we identify a role for the deubiquitinase Usp7 in the maintenance of the SC in early prophase and show that its function in SC maintenance is independent

SUBMITTER: Lake CM 

PROVIDER: S-EPMC11388383 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature