Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis.

ABSTRACT: Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue damage. Depending on the anatomic setting, a chronic inflammatory disease can exert unique local and systemic influences, which provide an exceptional opportunity for understanding disease mechanism and testing therapeutic interventions. The oral cavity is an easily accessible environment that allows for protective interventions aiming at modulating the immune response to control disease processes driven by a breakdown of host-microbe homeostasis. Periodontal disease (PD) is a prevalent condition in which quantitative and qualitative changes of the oral microbiota (dysbiosis) trigger nonresolving chronic inflammation, progressive bone loss, and ultimately tooth

SUBMITTER: Shehabeldin M 

PROVIDER: S-EPMC11388407 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature