Stable Platform for Mevalonate Bioproduction from CO₂.

ABSTRACT: Stable production of value-added products using a microbial chassis is pivotal for determining the industrial suitability of the engineered biocatalyst. Microbial cells often lose the multicopy expression plasmids during long-term cultivations. Owing to the advantages related to titers, yields, and productivities when using a multicopy expression system compared with genomic integrations, plasmid stability is essential for industrially relevant biobased processes. Cupriavidus necator H16, a facultative chemolithoautotrophic bacterium, has been successfully engineered to convert inorganic carbon obtained from CO₂ fixation into value-added products. The application of this unique capability in the biotech industry has been hindered by C. necator H16 inability

SUBMITTER: Garavaglia M 

PROVIDER: S-EPMC11388446 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature