Impact of Annealing Chemistry on the Properties and Performance of Microporous Annealed Particle Hydrogels.

ABSTRACT: Microporous annealed particle (MAP) hydrogels are a promising class of in situ-forming scaffolds for tissue repair and regeneration. While an expansive toolkit of annealing chemistries has been described, the effects of different annealing chemistries on MAP hydrogel properties and performance have not been studied. In this study, we address this gap through a controlled head-to-head comparison of poly(ethylene glycol) (PEG)-based MAP hydrogels that were annealed using tetrazine-norbornene and thiol-norbornene click chemistry. Characterization of material properties revealed that tetrazine click annealing significantly increases MAP hydrogel shear storage modulus and results in slower in vitro degradation kinetics when microgels with a higher cross-link density are used. However, these eff

SUBMITTER: Recalde Phillips SY 

PROVIDER: S-EPMC11388458 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature