Feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in awake mice.

ABSTRACT:

Aims

Transcutaneous auricular vagus nerve stimulation (taVNS) is widely used to treat a variety of disorders because it is noninvasive, safe, and well tolerated by awake patients. However, long-term and repetitive taVNS is difficult to achieve in awake mice. Therefore, developing a new taVNS method that fully mimics the method used in clinical settings and is well-tolerated by awake mice is greatly important for generalizing research findings related to the effects of taVNS. The study aimed to develop a new taVNS device for use in awake mice and to test its reliability and effectiveness.

Methods

We demonstrated the reliability of this taVNS device through retrograde neurotropic pseudorabies virus (PRV) tracing and evaluated its effectiveness through morphological analysis. A

SUBMITTER: Yu YM 

PROVIDER: S-EPMC11388527 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature