High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics.

ABSTRACT:

Background

Sepsis-associated encephalopathy (SAE) is a neuronal injury with poor prognosis. Mitochondrial dysfunction is critical in SAE development, and hydrogen gas (H₂) has a protective effect on septic mice. This study aimed to investigate the effect of high concentration (67%) of H₂ on SAE and whether it is related to mitochondrial biogenesis and mitochondrial dynamics.

Methods

A mouse sepsis model was induced by cecal ligation and puncture. The mice inhalated 67% H₂ for 1 h at 1 and 6 h post-surgery, respectively. The 7-day survival rate was recorded. Cognitive function was assessed using the Y-maze test and Morris water maze test. Serum inflammatory factors, antioxidant enzymes, as well as mitochondrial function indexes including mitoc

SUBMITTER: Cui Y 

PROVIDER: S-EPMC11388582 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature