SARS-CoV-2 infections before, during, and after the Omicron wave: a 2-year Indian community cohort study.

ABSTRACT:

Background

We measured the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and re-infections in an adult community-based cohort in southern India.

Methods

We conducted a 2-year follow-up on 1229 participants enrolled between May and October 2021. Participants provided vaccination histories, weekly saliva samples, and blood samples at 0, 6, 12, and 24 months. Salivary reverse transcription polymerase chain reaction (RT-PCR) and Meso-Scale Discovery panels were used for SARS-CoV-2 detection and anti-spike, anti-nucleocapsid immunoglobulin G quantification. Whole genome sequencing was performed on a subset of positive samples. SARS-CoV-2 infection incidence was measured across Pre-Omicron (May-December 2021), Omicron-I (December 2021-June 20

SUBMITTER: Madhavan R 

PROVIDER: S-EPMC11388673 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature