PH modulates efficiency of singlet oxygen production by flavin cofactors.

ABSTRACT: Flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) are frequently used interchangeably in the catalysis of various reactions as part of flavoenzymes because they have the same functional component, the isoalloxazine ring. However, they differ significantly in their conformational properties. The inclusion of two planar rings in the structure of FAD greatly increases the range of possible conformations compared to FMN. An exemplary instance of this is the remarkable disparity in singlet oxygen efficiency production, Φ _Δ, between FMN and FAD. Under neutral pH conditions, FAD has low photosensitizing activity with Φ _Δ ∼ 0.07 while FMN demonstrates high photosensitizing activity with Φ _Δ ∼ 0.6. Both adenine rings and isoallox

SUBMITTER: Hovan A 

PROVIDER: S-EPMC11388723 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature