First line therapy in stage IV BRAF mutated colorectal cancer.

ABSTRACT:

Introduction

The molecular profile of colorectal cancer (CRC) plays a crucial role in understanding patient prognosis and treatment response. Within CRC, a distinct subgroup can be identified by the presence of the BRAF V600E mutation. This specific mutation, classified as Class I of BRAF mutations, is known to be associated with a poor prognosis and resistance to standard therapy. To determine the most effective treatment approach for this specific subgroup of CRC, we conducted a network meta-analysis (NMA) to compare various pharmacological interventions and evaluate their relative effectiveness in BRAF-mutated CRCs.

Materials and methods

On July 31, 2023, we conducted a systematic search of PubMed, Cochrane Central Register of Controlled Trials, and Embase. The inclusion

SUBMITTER: Petrelli F 

PROVIDER: S-EPMC11388748 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature