Unraveling the relevance of SARS-Cov-2 infection and ferroptosis within the heart of COVID-19 patients.

ABSTRACT:

Background

The coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to a huge mortality rate and imposed significant costs on the health system, causing severe damage to the cells of different organs such as the heart. However, the exact details and mechanisms behind this damage are not clarified. Therefore, we aimed to identify the cell and molecular mechanism behind the heart damage caused by SARS-Cov-2 infection.

Methods

RNA-seq data for COVID-19 patients' hearts was analyzed to obtain differentially expressed genes (DEGs) and differentially expressed ferroptosis-related genes (DEFRGs). Then, DEFRGs were used for analyzing GO and KEGG enrichment, and perdition of metabolites and drugs. we also constructe

SUBMITTER: Alizadeh Saghati A 

PROVIDER: S-EPMC11388749 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature