Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning.

ABSTRACT:

Background

Anhedonia is a deficit of dynamic reward process, and a large proportion of schizophrenia patients continue to experience anhedonia even during the stable phase. However, few studies have examined the multiple aspects of performance in reward processing in patients with stable schizophrenia and evidence suggests that physical and cognitive effort may involve different neural mechanisms.

Methods

Parallel measures of effort-based expenditure for reward tasks (EEfRT) and self-report questionnaires of pleasure were applied in 61 patients with stable schizophrenia (SSZ) and 46 healthy controls (HCs), and percentages of hard task choices (HTC%) were used to assess motivation in reward processing. Negative symptoms, neurocognitive and social function were evaluated in SS

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11388758 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature