Characteristics of two different immune infiltrating pyroptosis subtypes in ischemic stroke.

ABSTRACT:

Background

Ischemic stroke (IS) is a serious health hazard and identified as the second leading cause of mortality around the world. However, the role of pyroptosis in the immune microenvironment regulation in IS is still unclear. Here, our study aims to elucidate the effect of pyroptosis on immune microenvironment in IS.

Methods

The regulation mode of pyroptosis in IS was systematically evaluated, and its effects on immune microenvironment were explored, including infiltration of immune cells, immune response gene sets, and human leukocyte antigen (HLA) gene. The genes and drugs related to pyroptosis phenotype were also identified. An MCAO rat model was constructed, and the mRNA expression levels in the classifier model were validated by qRT-PCR.

Results

The separato

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11388774 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature