Biofluid GPNMB/osteoactivin as a potential biomarker of ageing: A cross-sectional study.

ABSTRACT:

Background

Glycoprotein non-metastatic melanoma B (GPNMB)/osteoactivin was first identified in the human melanoma cell lines. GPNMB plays a key role in the anti-inflammatory and antioxidative functions as well as osteoblast differentiation, cancer progression, and tissue regeneration. Recently, GPNMB was used as an anti-aging vaccine for mice. The present study aimed to investigate the potential of biofluid GPNMB as an aging biomarker in humans using serum and urine samples from an aging Chinese population.

Methods

We analyzed RNA-sequencing data (GSE132040) from 17 murine organs across different ages to assess the gene expression of potential ageing biomarkers. Spearman's correlation coefficients were used to evaluate the relationship between gene expression and age. Meanwh

SUBMITTER: Liu YY 

PROVIDER: S-EPMC11388787 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature