Effects of the FHL2 gene on the development of subcutaneous and intramuscular adipocytes in goats.

ABSTRACT:

Background

Adipose tissue affects not only the meat quality of domestic animals, but also human health. Adipocyte differentiation is regulated by a series of regulatory genes and cyclins. Four and half-LIM protein (FHL2) is positively correlated with the hypertrophy of adipocytes and can cause symptoms such as obesity and diabetes.

Result

In the transcriptome sequencing analysis of intramuscular adipocytes after three days of differentiation, the differentially expressed gene FHL2 was found. To further explore the biological significance of the differentially expressed gene FHL2, which was downregulated in the mature adipocytes. We revealed the function of FHL2 in adipogenesis through the acquisition and loss of function of FHL2. The results showed that the overexpression of

SUBMITTER: Li A 

PROVIDER: S-EPMC11389066 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature