Association of procalcitonin with voriconazole concentrations: a retrospective cohort study.

ABSTRACT: Inflammation is a potential risk factor of voriconazole (VCZ) overdose, procalcitonin (PCT) is reported to act as a diagnostic marker for bacterial infections. However, the association of PCT with VCZ trough serum concentrations (VCZ-C_min) is not fully clear. Our study aims to investigate the associations between PCT and VCZ-C_min. In this retrospective cohort study, we collected the clinical data of 147 patients who received VCZ and monitored the VCZ concentration of them in our hospital from August 2017 to August 2021. All patients underwent routine clinical examinations on the day or the day before VCZ administration. General information and clinical symptoms of these patients were recorded. Multivariate liner analysis showed that PCT was significantly associated wi

SUBMITTER: Zhou JX 

PROVIDER: S-EPMC11389108 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature